Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 169)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1173631	0.1238408	0.3540646
Weighted median	23	0.0733667	0.0579877	0.2057958
Inverse variance weighted	23	0.0426665	0.0477720	0.3717892
Simple mode	23	0.1201663	0.1099696	0.2863370
Weighted mode	23	0.0845371	0.0779862	0.2901018

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.32312	21	0.0542826
Inverse variance weighted	32.98407	22	0.0620983

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0045871	0.0070001	0.5193934

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010357	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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