Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 168)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1364801	0.0998203	0.1860023
Weighted median	23	-0.0310798	0.0575029	0.5888583
Inverse variance weighted	23	0.0051769	0.0397905	0.8964835
Simple mode	23	-0.0222024	0.1146718	0.8482522
Weighted mode	23	-0.0522072	0.0688923	0.4566066

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.50576	21	0.4894591
Inverse variance weighted	22.88280	22	0.4083727

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0086992	0.0056423	0.1380657

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006939	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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