Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 167)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1121086	0.1010382	0.2797309
Weighted median	23	0.0374350	0.0566833	0.5089820
Inverse variance weighted	23	0.0027877	0.0399610	0.9443852
Simple mode	23	0.0259208	0.0938269	0.7849256
Weighted mode	23	0.0145534	0.0609162	0.8133882

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.51521	21	0.4278912
Inverse variance weighted	23.07895	22	0.3972829

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0070557	0.0057112	0.2303127

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006995	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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