Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 166)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0562965	0.1051744	0.5980877
Weighted median	23	-0.0180625	0.0607246	0.7661235
Inverse variance weighted	23	-0.0070443	0.0405703	0.8621543
Simple mode	23	-0.0748719	0.1113341	0.5082691
Weighted mode	23	-0.0313577	0.0854245	0.7170664

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.31333	21	0.3275025
Inverse variance weighted	23.78859	22	0.3584080

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0038898	0.005945	0.5200244

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007218	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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