Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 165)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1875313	0.0998198	0.0742392
Weighted median	23	0.0457351	0.0586320	0.4353691
Inverse variance weighted	23	0.0120819	0.0399980	0.7626051
Simple mode	23	0.0687749	0.1117212	0.5444794
Weighted mode	23	0.0657255	0.0717734	0.3697343

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.47556	21	0.5546617
Inverse variance weighted	23.12201	22	0.3948679

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0107744	0.0056423	0.0699455

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007036	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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