Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 164)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0316247	0.1072229	0.7709332
Weighted median	23	0.0278367	0.0563475	0.6212932
Inverse variance weighted	23	0.0456840	0.0409652	0.2647694
Simple mode	23	0.0271739	0.0897384	0.7648778
Weighted mode	23	0.0237572	0.0658197	0.7215840

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.23030	21	0.2820343
Inverse variance weighted	24.25371	22	0.3340722

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0008634	0.0060607	0.8880793

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007765	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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