Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 163)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2453341	0.1227037	0.0586693
Weighted median	23	0.0311621	0.0572843	0.5864483
Inverse variance weighted	23	-0.0424863	0.0536154	0.4281112
Simple mode	23	0.0130363	0.1121555	0.9085215
Weighted mode	23	0.0130363	0.0663282	0.8459899

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.73281	21	0.0622971
Inverse variance weighted	41.54615	22	0.0070906

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0176748	0.0069357	0.0187096

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012948	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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