Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 162)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2725858	0.1313857	0.0504962
Weighted median	23	0.0346759	0.0609716	0.5695447
Inverse variance weighted	23	0.0605792	0.0537184	0.2594391
Simple mode	23	-0.0091250	0.1449160	0.9503609
Weighted mode	23	0.0308331	0.0836942	0.7160949

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.38349	21	0.0197923
Inverse variance weighted	41.70808	22	0.0067796

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0130194	0.0074266	0.0941767

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013368	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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