Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 161)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1902560	0.1009169	0.0733055
Weighted median	23	0.0044981	0.0650646	0.9448841
Inverse variance weighted	23	0.0041587	0.0423663	0.9218052
Simple mode	23	0.0662162	0.1342759	0.6268034
Weighted mode	23	0.0269483	0.0887603	0.7642793

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.46420	21	0.4309269
Inverse variance weighted	25.94159	22	0.2541985

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.011939	0.0057043	0.0486731

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007864	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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