Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 160)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1094966	0.1165767	0.3582727
Weighted median	23	-0.0318795	0.0562432	0.5708396
Inverse variance weighted	23	0.0005945	0.0456197	0.9896029
Simple mode	23	0.0489186	0.1006791	0.6318524
Weighted mode	23	-0.0020708	0.0680185	0.9759867

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.64262	21	0.1228494
Inverse variance weighted	30.07835	22	0.1165725

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0067607	0.0065895	0.3165733

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009114	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8