Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 16)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0435588	0.0998206	0.6670213
Weighted median	23	-0.0122473	0.0554353	0.8251478
Inverse variance weighted	23	0.0192007	0.0390156	0.6226286
Simple mode	23	-0.0384494	0.0869995	0.6628395
Weighted mode	23	-0.0187224	0.0611338	0.7622915

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.05329	21	0.5178884
Inverse variance weighted	20.12357	22	0.5753105

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0014958	0.0056423	0.7935114

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006171	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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