Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 159)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0361259	0.1125932	0.7514924
Weighted median	23	0.0345988	0.0563826	0.5394508
Inverse variance weighted	23	0.0283214	0.0433904	0.5139425
Simple mode	23	-0.0108898	0.0955605	0.9103053
Weighted mode	23	-0.0028307	0.0655579	0.9659483

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.71825	21	0.1803747
Inverse variance weighted	27.21026	22	0.2033491

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0039577	0.0063643	0.5407272

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008405	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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