Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 158)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1513038	0.1237028	0.2348318
Weighted median	23	0.0701139	0.0618270	0.2567803
Inverse variance weighted	23	0.0314466	0.0484693	0.5164719
Simple mode	23	0.0530415	0.1092924	0.6322495
Weighted mode	23	0.0743739	0.0708671	0.3053485

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.25221	21	0.0551951
Inverse variance weighted	33.95402	22	0.0496555

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0073605	0.0069923	0.3044628

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010485	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8