Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 156)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1710499	0.0998192	0.1013277
Weighted median	23	-0.0369051	0.0569097	0.5166717
Inverse variance weighted	23	-0.0440352	0.0390155	0.2590418
Simple mode	23	0.0160407	0.0955889	0.8682667
Weighted mode	23	-0.1171258	0.0735182	0.1253929

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.69728	21	0.8822478
Inverse variance weighted	15.60837	22	0.8348359

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0078	0.0056423	0.1813698

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005116	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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