Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 155)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0471561	0.0998203	0.6415065
Weighted median	23	-0.0435699	0.0598977	0.4669785
Inverse variance weighted	23	-0.0600533	0.0390835	0.1244070
Simple mode	23	-0.1621291	0.1106601	0.1570373
Weighted mode	23	-0.0316575	0.0726328	0.6671871

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.71528	21	0.4764456
Inverse variance weighted	22.07681	22	0.4553121

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0065837	0.0056423	0.2563529

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007408	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8