Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 154)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0418911	0.0998209	0.6789939
Weighted median	23	-0.0241075	0.0550709	0.6615644
Inverse variance weighted	23	0.0250131	0.0390157	0.5214556
Simple mode	23	-0.0352308	0.0923459	0.7064856
Weighted mode	23	-0.0300137	0.0630993	0.6390071

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.16275	21	0.7011948
Inverse variance weighted	17.19649	22	0.7524248

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0010365	0.0056424	0.8560141

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005336	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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