Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 153)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0420749	0.1186257	0.7263614
Weighted median	23	0.0497065	0.0562151	0.3765783
Inverse variance weighted	23	0.0357069	0.0453035	0.4305968
Simple mode	23	0.0401682	0.0898597	0.6592372
Weighted mode	23	0.0573953	0.0607121	0.3547392

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.6581	21	0.0990769
Inverse variance weighted	29.6629	22	0.1268905

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0003911	0.0067053	0.9540443

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009242	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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