Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 151)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0232622	0.1030218	0.8235410
Weighted median	23	-0.0259336	0.0598170	0.6646161
Inverse variance weighted	23	-0.0213830	0.0393415	0.5867708
Simple mode	23	0.0954275	0.0977983	0.3397921
Weighted mode	23	0.0410654	0.0745079	0.5870817

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.36884	21	0.3785291
Inverse variance weighted	22.36926	22	0.4380422

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0001154	0.0058233	0.9843761

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006869	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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