Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 150)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1118948	0.0998197	0.2749569
Weighted median	23	-0.0613293	0.0574057	0.2853637
Inverse variance weighted	23	0.0010811	0.0390153	0.9778943
Simple mode	23	-0.0384278	0.0981418	0.6991550
Weighted mode	23	-0.0794394	0.0852012	0.3612633

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.33462	21	0.6277414
Inverse variance weighted	19.84657	22	0.5926367

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0069379	0.0056423	0.2324408

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006014	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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