Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 149)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0647227	0.0998194	0.5237550
Weighted median	23	0.0261243	0.0572345	0.6480716
Inverse variance weighted	23	0.0388610	0.0390152	0.3192269
Simple mode	23	0.0294478	0.1011196	0.7736130
Weighted mode	23	0.0341626	0.0819443	0.6807913

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.68673	21	0.7299122
Inverse variance weighted	16.76596	22	0.7761431

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0015882	0.0056423	0.7811001

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005381	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

Funnel plot

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Leave-one-out sensitivity analysis

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