Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 148)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0230241	0.0998198	0.8198135
Weighted median	23	0.0676782	0.0572058	0.2367833
Inverse variance weighted	23	0.0541708	0.0390155	0.1650023
Simple mode	23	0.1086497	0.0923095	0.2517673
Weighted mode	23	0.0563557	0.0704286	0.4321616

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.01717	21	0.5201741
Inverse variance weighted	20.72307	22	0.5379048

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0047405	0.0056423	0.4102721

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006864	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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