Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 147)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0904457	0.0998191	0.3751647
Weighted median	23	0.0999507	0.0547708	0.0680172
Inverse variance weighted	23	0.0972590	0.0390156	0.0126731
Simple mode	23	0.0918754	0.0834139	0.2826100
Weighted mode	23	0.1054823	0.0603882	0.0946314

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.55442	21	0.4864274
Inverse variance weighted	20.55992	22	0.5480591

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0004184	0.0056423	0.9415885

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008113	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8