Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 146)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1000570	0.1000317	0.3285750
Weighted median	23	0.1240384	0.0580354	0.0325745
Inverse variance weighted	23	0.0444908	0.0390153	0.2541437
Simple mode	23	0.1329530	0.1005607	0.1997117
Weighted mode	23	0.1473851	0.0764597	0.0669116

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.08974	21	0.4534754
Inverse variance weighted	21.45550	22	0.4927605

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0034124	0.0056543	0.552643

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006896	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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