Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 144)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0914041	0.1022615	0.3815440
Weighted median	23	0.0380487	0.0544935	0.4850361
Inverse variance weighted	23	0.0458976	0.0392673	0.2424640
Simple mode	23	0.0210716	0.0911020	0.8192219
Weighted mode	23	0.0243714	0.0618343	0.6972714

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.03958	21	0.3972322
Inverse variance weighted	22.28488	22	0.4429986

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0027945	0.0057803	0.6337718

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007172	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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