Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 143)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0764303	0.1243325	0.5453399
Weighted median	23	-0.0327966	0.0636325	0.6062694
Inverse variance weighted	23	-0.0579756	0.0475086	0.2223443
Simple mode	23	0.0398984	0.1163008	0.7348081
Weighted mode	23	0.0056929	0.0823599	0.9455166

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.58088	21	0.0510761
Inverse variance weighted	32.62123	22	0.0674044

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0011333	0.0070279	0.873431

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010554	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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