Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 142)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0028595	0.0998205	0.9774168
Weighted median	23	0.0060966	0.0557631	0.9129407
Inverse variance weighted	23	0.0257840	0.0390158	0.5087013
Simple mode	23	0.0042345	0.0936366	0.9643374
Weighted mode	23	0.0195245	0.0594837	0.7458397

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.75504	21	0.6644487
Inverse variance weighted	17.81730	22	0.7167642

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0014078	0.0056423	0.8053941

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005532	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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