Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 141)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1549251	0.0998198	0.1355922
Weighted median	23	-0.0076795	0.0569336	0.8927024
Inverse variance weighted	23	-0.0116815	0.0390154	0.7646297
Simple mode	23	-0.0038602	0.1102040	0.9723735
Weighted mode	23	0.0581279	0.0693738	0.4111010

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.97267	21	0.7127617
Inverse variance weighted	20.26080	22	0.5667300

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0102313	0.0056423	0.0841013

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006167	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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