Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 140)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0493237	0.0998212	0.6263499
Weighted median	23	0.0391356	0.0554722	0.4804994
Inverse variance weighted	23	0.0578257	0.0390158	0.1383111
Simple mode	23	0.0137157	0.0960612	0.8877631
Weighted mode	23	0.0402762	0.0668210	0.5528395

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.70196	21	0.6677793
Inverse variance weighted	17.71052	22	0.7230071

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0005221	0.0056424	0.9271522

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006032	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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