Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 14)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0026725	0.0998206	0.9788933
Weighted median	23	0.0011210	0.0559649	0.9840194
Inverse variance weighted	23	-0.0029751	0.0390159	0.9392168
Simple mode	23	0.0045418	0.0907112	0.9605198
Weighted mode	23	-0.0025790	0.0714241	0.9715215

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.11398	21	0.9045791
Inverse variance weighted	13.11776	22	0.9298249

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0003468	0.0056424	0.9515679

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003977	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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