Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 139)

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 -0.0248898 0.1046900 0.8143815
Weighted median 23 -0.0246205 0.0569068 0.6652717
Inverse variance weighted 23 0.0280197 0.0402641 0.4864925
Simple mode 23 -0.0223409 0.0988735 0.8233226
Weighted mode 23 -0.0439399 0.0586004 0.4613056

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 23.09891 21 0.3387277
Inverse variance weighted 23.43052 22 0.3777713

Test for directional horizontal pleiotropy

egger_intercept se pval
0.0032492 0.0059176 0.5887489

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0007256 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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