Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 138)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0769823	0.1094744	0.4896549
Weighted median	23	0.0365619	0.0613878	0.5514506
Inverse variance weighted	23	0.0203951	0.0421181	0.6282179
Simple mode	23	-0.0929476	0.1045343	0.3835374
Weighted mode	23	0.0664907	0.0805308	0.4178636

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.25894	21	0.2361236
Inverse variance weighted	25.63826	22	0.2675370

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.003475	0.006188	0.5803522

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007851	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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