Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 137)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0767845	0.0998204	0.4503247
Weighted median	23	-0.0700568	0.0573977	0.2222565
Inverse variance weighted	23	-0.0628734	0.0390155	0.1070717
Simple mode	23	-0.0328618	0.1006425	0.7471169
Weighted mode	23	-0.0580045	0.0775979	0.4626774

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.54201	21	0.8452120
Inverse variance weighted	14.56493	22	0.8802229

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0008543	0.0056424	0.8811008

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005201	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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