Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 136)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0184823	0.1159339	0.8748602
Weighted median	23	0.0068821	0.0592104	0.9074686
Inverse variance weighted	23	0.0405912	0.0445940	0.3626959
Simple mode	23	0.0454843	0.0955306	0.6386812
Weighted mode	23	0.0222792	0.0646496	0.7336567

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.32776	21	0.1310983
Inverse variance weighted	28.74114	22	0.1524008

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0036277	0.0065531	0.5857111

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009037	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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