Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 135)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0368397	0.0998208	0.7157793
Weighted median	23	0.0315079	0.0576206	0.5845050
Inverse variance weighted	23	0.0264452	0.0390156	0.4978923
Simple mode	23	-0.0288981	0.1068676	0.7893651
Weighted mode	23	0.0198521	0.0731721	0.7886845

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.5560	21	0.7940559
Inverse variance weighted	15.5688	22	0.8366948

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0006383	0.0056424	0.9110009

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004857	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8