Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 134)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0933400	0.1172602	0.4349345
Weighted median	23	-0.0818968	0.0574343	0.1538909
Inverse variance weighted	23	-0.0434684	0.0464600	0.3494743
Simple mode	23	-0.1042841	0.0984357	0.3009050
Weighted mode	23	-0.0851743	0.0616686	0.1810987

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.97995	21	0.1144838
Inverse variance weighted	31.19713	22	0.0921517

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0084014	0.0066281	0.2188379

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009829	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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