Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 133)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1126754	0.0998207	0.2717222
Weighted median	23	0.0150121	0.0551074	0.7853028
Inverse variance weighted	23	0.0054153	0.0390157	0.8896102
Simple mode	23	0.0367269	0.0888032	0.6831878
Weighted mode	23	0.0270354	0.0666031	0.6887235

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.99489	21	0.9397558
Inverse variance weighted	13.35769	22	0.9227030

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0065868	0.0056424	0.2561368

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004054	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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