Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 131)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1386155	0.0998193	0.1794887
Weighted median	23	-0.0850361	0.0557979	0.1275087
Inverse variance weighted	23	-0.0643945	0.0390155	0.0988436
Simple mode	23	-0.0486254	0.0967233	0.6201518
Weighted mode	23	-0.0876939	0.0614332	0.1674863

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.91640	21	0.4640599
Inverse variance weighted	21.56897	22	0.4858534

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0045579	0.0056423	0.4282524

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007362	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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