Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 130)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1627766	0.1084152	0.1481350
Weighted median	23	-0.0415022	0.0573575	0.4693293
Inverse variance weighted	23	0.0137993	0.0443796	0.7558477
Simple mode	23	0.0836295	0.1133146	0.4682969
Weighted mode	23	-0.0676820	0.0723138	0.3594608

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.77230	21	0.2571606
Inverse variance weighted	28.46571	22	0.1607562

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0108436	0.0061282	0.0913388

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008663	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8