Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 13)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0087013	0.0998201	0.9313623
Weighted median	23	-0.0070266	0.0578865	0.9033852
Inverse variance weighted	23	0.0059026	0.0390155	0.8797489
Simple mode	23	0.0927349	0.0971375	0.3501146
Weighted mode	23	0.0035521	0.0646867	0.9567045

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.98966	21	0.6496586
Inverse variance weighted	17.99059	22	0.7065463

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0001719	0.0056423	0.975987

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005459	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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