Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 128)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1746540	0.0998204	0.0947737
Weighted median	23	0.0506635	0.0564548	0.3694963
Inverse variance weighted	23	0.0265706	0.0390155	0.4958545
Simple mode	23	-0.0413440	0.0918181	0.6569130
Weighted mode	23	0.1016988	0.0646377	0.1299064

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.13419	21	0.8161586
Inverse variance weighted	17.73179	22	0.7217665

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0090938	0.0056424	0.1219546

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005514	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8