Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 127)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0176444	0.0998213	0.8613906
Weighted median	23	0.0291321	0.0565636	0.6065305
Inverse variance weighted	23	0.0559159	0.0390159	0.1518132
Simple mode	23	0.0150774	0.0816175	0.8551309
Weighted mode	23	0.0256989	0.0614268	0.6797346

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.5812	21	0.4847612
Inverse variance weighted	20.7547	22	0.5359390

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0023502	0.0056424	0.6812449

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006911	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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