Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 126)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1290800	0.1052401	0.2335749
Weighted median	23	0.0499068	0.0552224	0.3661326
Inverse variance weighted	23	0.0373341	0.0410375	0.3629509
Simple mode	23	0.1492951	0.1059170	0.1726534
Weighted mode	23	0.0836533	0.0626385	0.1953688

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.34239	21	0.3259979
Inverse variance weighted	24.33949	22	0.3296892

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0056341	0.0059487	0.3543501

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007653	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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