Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 125)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1573512	0.1518340	0.3118318
Weighted median	23	-0.0758581	0.0608368	0.2124304
Inverse variance weighted	23	0.0026171	0.0597632	0.9650710
Simple mode	23	-0.0938033	0.1046113	0.3795952
Weighted mode	23	-0.1024709	0.0776915	0.2007519

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	48.59015	21	0.0005712
Inverse variance weighted	51.62166	22	0.0003525

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0098236	0.0085823	0.2652414

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015642	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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