Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 124)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2273240	0.1036308	0.0396590
Weighted median	23	0.0065377	0.0562519	0.9074774
Inverse variance weighted	23	0.0006439	0.0445787	0.9884759
Simple mode	23	-0.0574174	0.1072981	0.5979342
Weighted mode	23	0.0364070	0.0643448	0.5772485

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.63448	21	0.3637722
Inverse variance weighted	28.72144	22	0.1529869

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0139205	0.0058578	0.0270709

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008703	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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