Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 123)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0185187	0.1148475	0.8734406
Weighted median	23	0.0464051	0.0601255	0.4402302
Inverse variance weighted	23	0.0253150	0.0438616	0.5638342
Simple mode	23	0.0189945	0.0984777	0.8488217
Weighted mode	23	0.0545232	0.0676776	0.4290781

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.79944	21	0.1459316
Inverse variance weighted	27.80491	22	0.1822370

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0004174	0.0064918	0.9493471

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008553	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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