Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 122)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1070002	0.1125256	0.3524736
Weighted median	23	0.0442268	0.0566067	0.4346259
Inverse variance weighted	23	0.0364986	0.0448919	0.4161987
Simple mode	23	0.1161866	0.0883260	0.2019113
Weighted mode	23	0.0635544	0.0581359	0.2861312

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.68703	21	0.1814541
Inverse variance weighted	29.12639	22	0.1412876

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0088123	0.0063605	0.1804491

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000909	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8