Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 121)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0497324	0.1187346	0.6795762
Weighted median	23	-0.0402212	0.0663526	0.5443997
Inverse variance weighted	23	-0.0444521	0.0453444	0.3269263
Simple mode	23	0.0824722	0.1369866	0.5532984
Weighted mode	23	0.0792716	0.1281749	0.5426204

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.71395	21	0.0978886
Inverse variance weighted	29.71726	22	0.1255000

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0003243	0.0067116	0.961922

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009398	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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