Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 120)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1290157	0.1235343	0.3081871
Weighted median	23	-0.0043304	0.0670484	0.9485034
Inverse variance weighted	23	-0.0595850	0.0475917	0.2105682
Simple mode	23	0.0566495	0.1468185	0.7033157
Weighted mode	23	0.0788263	0.1325035	0.5579801

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.16512	21	0.0563342
Inverse variance weighted	32.73620	22	0.0656823

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0042638	0.0069829	0.5480098

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010626	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8