Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 12)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1198014	0.1254175	0.3503338
Weighted median	23	0.0236018	0.0652968	0.7177595
Inverse variance weighted	23	0.0385292	0.0484551	0.4265245
Simple mode	23	0.1200197	0.1054113	0.2671234
Weighted mode	23	-0.0052672	0.0773354	0.9463142

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.15163	21	0.0445626
Inverse variance weighted	33.93407	22	0.0498876

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0049909	0.0070892	0.4891563

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010578	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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