Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 119)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1885473	0.1108365	0.1036805
Weighted median	23	0.0751457	0.0586550	0.2001422
Inverse variance weighted	23	0.1128151	0.0428772	0.0085105
Simple mode	23	0.1407321	0.1162176	0.2387686
Weighted mode	23	0.0965482	0.0797013	0.2386036

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.89195	21	0.2105991
Inverse variance weighted	26.57137	22	0.2279599

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0046508	0.0062651	0.4661096

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010585	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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